Myo & D‑Chiro Inositol + MTHF Folate & Vitamin D3 Powder

Each scoop provides 2,000 mg of Myo-Inositol and 50 mg of D-Chiro Inositol (a 40:1 ratio), with folate as L-5-MTHF and vitamin D3, to support normal cell function as part of a balanced diet.*

Tested and certified by independent groups
  • Clean Label Project says this product tested in the best one-third of its category for the contaminants it screens.
  • An outside group tested this product for heavy metals, pesticides and plastic chemicals that labels do not list.
  • NSF checked that what is in the bottle matches the label, and tested for certain contaminants.
  • NSF tested this product and audited where it is made to check it meets a gluten-free limit.
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255 ratings and reviews by women like you89% rate us 4 or 5 stars

What customers say

4.6

255 ratings and reviews

89% rated 4 or 5 stars

32 written reviews. Featured reviews come first. Tap a star row or change the sort to see every rating, including the lowest.

Verified purchase

Extra benefits with no weird taste.

I was a little worried that the folate and vitamin D would make this powder taste bad (I'm very picky about taste), but I decided to try it since the original one is 100% flavorless. This one did not disappoint. I can't taste anything, even when I mix it in water. I love that I can get folate and vitamin D along with my inositol and not even have to swallow another pill or put up with a weird flavor. 100% a win!

JB
Verified purchase

I’ve been really happy with this powder. It’s easy to measure and mix, and it’s simple to add to my daily routine. The container was packaged well and lasts a good amount of time. I would purchase it again!

Amazon customer

Noticed a difference with my cycles. Take a few months to see the benefits, which is normal as this have an effect on your hormones. Do your research before buying, do not use blindly, but great product!

Amazon customer
Verified purchase

Excelente producto pero es un abuso el tamano de la presentacion😭😩 para el precio, es muy pequeño, ese fresco solo da para algunas 5 cucharaditas😭y pague 40 dolares por el. Es abusivo.

Amazon customer
Verified purchase

I’ve gotten this more than once. I like it. It’s a white powder. It doesn’t have a taste but it taste kind of sweet at the same time. If that makes sense.

Amazon customer
Verified purchase

Excellent product, I recommend it and I've used it several times. Highly recommended; it makes a noticeable difference.

Amazon customer

Reviews are the personal opinions and experiences of individual customers. Wholesome Story did not pay or reward anyone for them, and we do not edit them. They are not our claims. Wholesome Story products are not intended to diagnose, treat, cure, or prevent any disease, and individual results vary.

Real orders from our customers

How our customers take it.

Out of every 10 orders for our inositol, 6 are reorders.

Your first year
  1. Oct1
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  5. Feb5
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Half of the customers who reorder are still ordering into Jul. 1 in 4 go on past month 22.

9.2 monthsHalf of the customers who reorder keep ordering for 9.2 months or more.
6 in 10keep ordering for half a year or more.
1 in 4keep ordering for 22 months or more.

Life gets busy. About 1 in 4 took a year or more off, then came back to us.

This counts all our inositol products together: capsules, powder, the version with folate and vitamin D3, and every size.

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On our store, 3 in 4 reorders arrive by subscription: save 10%, plus $5 off your first subscription.

Based on real orders from our customers, on Amazon and on our store, as of October 2026.

Learn the basics

What is in this formula?

This powder combines two forms of inositol, a sugar alcohol, with folate as L-5-MTHF, a B vitamin, and vitamin D3, also called cholecalciferol.

In three steps

  1. Four active ingredients

    Each scoop has two inositols, folate as L-5-MTHF and vitamin D3.

  2. A 40 to 1 ratio

    Each scoop has 2,000 mg of Myo-Inositol and 50 mg of D-Chiro Inositol.

  3. One scoop per serving

    One serving is 1 heaping scoop (2.2 g), mixed into a drink as directed on the label.

Quick facts about this formula
FormatPowder. One serving is 1 scoop (2.2 g).
Myo-Inositol per scoop2,000 mg. Daily Value not established.
D-Chiro Inositol per scoop50 mg. Daily Value not established.
Folate per scoop500 mcg DFE, as L-5-Methyltetrahydrofolate. That is 125% of the Daily Value.
Vitamin D3 per scoop25 mcg, as Cholecalciferol. That is 125% of the Daily Value.
Ratio of the two inositols40 to 1. That is 2,000 mg to 50 mg.
Servings per containerAbout 30, in a container of 2.33 oz (66 g).
Other ingredientsNot listed here. Please read the label on your container.
What inositol isA sugar alcohol with nine forms. Myo-inositol is the most common one.
What L-5-MTHF isA form of folate. It is the main form of folate in blood plasma.
What vitamin D3 isCholecalciferol, one of the two main forms of vitamin D.
Plant source of our inositolOur inositol is currently sourced from corn.

Questions and answers

What exactly is in one scoop of the powder?

One serving is 1 scoop (2.2 g) with four active ingredients. It has 25 mcg of Vitamin D3 (as Cholecalciferol) and 500 mcg DFE of Folate (as L-5-Methyltetrahydrofolate). It also has 2,000 mg of Myo-Inositol and 50 mg of D-Chiro Inositol. One container holds 2.33 oz (66 g), which is about 30 servings.

One serving has 125% of the Daily Value for vitamin D3 and for folate. The two inositols have no established Daily Value. For other ingredients, please read the label on your container.

How do you mix the powder?

Mix one heaping scoop into a drink. Our label's words are: “Mix 1 heaping scoop (2.2 g) into any hot or cold beverage that is free of caffeine, sugar substitutes, or carbonation.” It adds: “Do not mix with alcoholic beverages.”

Follow the serving directions on the label. Read the full caution on the label, including the folate warning.

What does 40:1 mean?

40:1 is the ratio of the two inositols in each scoop. Each scoop has 2,000 mg of Myo-Inositol and 50 mg of D-Chiro Inositol. 2,000 divided by 50 is 40.

This is a fact about the formula. It is not a promise about results.

myo-inositol

What is myo-inositol?

Myo-inositol is a sugar alcohol, a molecule built much like a simple sugar. It has the same chemical formula as glucose, C6H12O6, but a different structure. Inositol comes in nine forms, and myo-inositol is the most common one.

Glucose is a simple sugar found in fruits and honey. Each scoop has 2,000 mg of Myo-Inositol.

6 more questions about myo-inositol
Where does myo-inositol come from?

Myo-inositol is found widely in plants and animals, and your body also makes it. A lab study of 487 foods found the most in fruits, beans, grains and nuts. In grains it is stored as phytic acid.

A US food rule describes inositol prepared from an extract of corn kernels. Our inositol is currently sourced from corn, and this can change.

What does inositol taste like?

Inositol tastes sweet. One history of inositol science says its early name, inosite, came from that sweet taste.

How does the body make, take in and break down myo-inositol?

Your body makes myo-inositol from glucose. Cells turn a form of glucose, glucose 6-phosphate, into inositol phosphate as the first step. Inositol is absorbed from the small intestine. The body also breaks myo-inositol down, and the first step opens its ring.

The enzyme for that step was isolated from pig kidneys. An enzyme is a substance that speeds up a chemical reaction in living things.

What do cells do with inositol?

Cells build myo-inositol into inositol lipids, which are fat-like molecules in the cell membrane. Cells also cut a small molecule, inositol trisphosphate, from one of these lipids. It carries a signal inside the cell. Provides Myo-Inositol and D-Chiro Inositol, two forms of inositol that cells use in cell signaling.*

The cell membrane is the thin layer that surrounds every living cell.

Where does the name myo-inositol come from?

Britannica says myo-inositol is named for muscle tissue, where it was first found in 1850. Scherer first isolated it and called it inosite. Maquenne fully purified it in 1887.

It was long counted as a B vitamin, but its status as a vitamin is uncertain.

What do researchers study about myo-inositol?

Researchers study how cells use inositol-containing molecules to pass signals. They measure how much myo-inositol common foods contain. They study how gut bacteria break down inositol from food.

These are topics of study. They are not claims about our product.

D-chiro-inositol

What is D-chiro-inositol?

D-chiro-inositol is one of the nine forms of inositol. The nine forms are stereoisomers. Stereoisomers have the same makeup, but their atoms are arranged differently in space. Myo-inositol is the leading form in nature, and the other forms are rarer.

Each scoop has 50 mg of D-Chiro Inositol.

3 more questions about D-chiro-inositol
Where does D-chiro-inositol come from?

D-chiro-inositol is found in some plants and has also been detected in mammals. Buckwheat seeds hold it joined to a sugar, in compounds called fagopyritols. Soybeans are rich in D-pinitol, a close chemical relative of D-chiro-inositol.

Our inositol is currently sourced from corn, and this can change.

How does the body make and break down D-chiro-inositol?

Animal studies show that tissues can turn myo-inositol into D-chiro-inositol. In one animal study, the share that was changed differed from tissue to tissue. The enzyme that breaks down myo-inositol also breaks down D-chiro-inositol, at a slower rate.

What do researchers study about D-chiro-inositol?

Researchers study how tissues turn myo-inositol into D-chiro-inositol. They also study how the two forms are absorbed when people take them together. These are topics of study, not claims about our product.

folate (L-5-MTHF)

What is folate as L-5-MTHF?

L-5-MTHF is one form of folate, a water-soluble B vitamin. The full name is L-5-methyltetrahydrofolate. 5-MTHF is the main form of folate in plasma, the liquid part of blood.

Folate was once called folacin. It is sometimes called vitamin B9.

5 more questions about folate (L-5-MTHF)
Where does folate come from?

Folate is found in many foods. Dark green leafy vegetables, fruits, nuts, beans, peas, eggs, dairy products, meat and grains all contain it. Fortified foods and most supplements use a form called folic acid. Some supplements use 5-MTHF, as ours does.

How does the body take in and store folate?

Your gut changes food folate to a simpler form before it absorbs it. Before folate enters the blood, the body changes it to methyl or formyl forms. About half of the body's folate is stored in the liver. Folate (as L-5-MTHF) plays a role in how your cells make DNA.*

What does 500 mcg DFE mean?

DFE stands for dietary folate equivalents. It is a unit made so that different forms of folate can be compared. Each scoop has 500 mcg DFE, which is 125% of the Daily Value.

NIH says the factors for changing 5-MTHF amounts into DFE have not been formally established.

Where does the name folate come from?

The name comes from the Latin word folium, which means leaf. In 1941, scientists described folic acid that they had taken from 4 tons of spinach.

What do researchers study about folate and 5-MTHF?

Researchers study how to measure the amount of folate in blood. They compare blood folate after people take folic acid or 5-MTHF. They also study how folate supplies the small carbon units that cells add to DNA.

These are topics of study. They are not claims about our product.

vitamin D3

What is vitamin D3?

Vitamin D3 is cholecalciferol, one of the two main forms of vitamin D. The other main form is vitamin D2, also called ergocalciferol. Vitamin D is a fat-soluble vitamin.

Each scoop has 25 mcg of Vitamin D3, as Cholecalciferol.

5 more questions about vitamin D3
Where does vitamin D3 come from?

Your skin makes vitamin D3 when UVB rays from sunlight reach it. Few foods contain vitamin D. Fatty fish and fish liver oils are among the top food sources.

Vitamin D3 for supplements is typically made from lanolin, which comes from sheep's wool. A version sourced from lichen also exists.

What does vitamin D3 look and smell like?

Pure vitamin D3 forms fine, colorless crystals. It has no smell. It does not dissolve in water.

How does the body take in and change vitamin D?

Vitamin D from sun, food or supplements is not active at first. The liver changes it to 25-hydroxyvitamin D. The kidneys then make the active form, 1,25-dihydroxyvitamin D. Vitamin D3 helps your body absorb and use calcium and phosphorus.*

Vitamin D is absorbed in the small intestine.

Where does the name vitamin D come from?

Vitamin D got its letter because it was found after vitamins A, B and C. Vitamin D2 was the first form to be isolated and identified. Scientists identified vitamin D3 in 1937.

What do researchers study about vitamin D3?

Researchers compare vitamin D2 and vitamin D3 supplements in trials. They measure a marker in blood called 25-hydroxyvitamin D. Expert panels also review studies to set daily intake values.

These are topics of study. They are not claims about our product.

Sources (34)

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Supplements you can trust.

The FDA does not test supplements before they are sold. So we ask independent groups to test ours. Each mark below says what it covers and what it does not.

  • 90-day guarantee
  • Blended in the USA with domestic and international ingredients
  • American company
Clean Label Project Purity AwardClean Label Project says this product tested in the best one-third of its category for the contaminants it screens.

What it checks

  • Clean Label Project buys top-selling products in a category and has independent labs test them for heavy metals, pesticides, glyphosate, phthalates and bisphenols.
  • Results are compared across the category. Only products in the best one-third earn the award.
  • The award is given to individual products, not to a whole brand.

What it does not mean

  • It does not mean the product has no contaminants.
  • It does not mean other products are unclean. Not winning is not a sign of a problem.

Look it up yourself

Clean Label Project CertifiedAn outside group tested this product for heavy metals, pesticides and plastic chemicals that labels do not list.

What it checks

  • A brand sends a product to Clean Label Project. Independent labs screen it for heavy metals, pesticides (including glyphosate), phthalates and bisphenols.
  • Clean Label Project judges each product on its own against limits set by product type.
  • Clean Label Project says certified products are tested again every year.

What it does not mean

  • It does not mean the product has zero contaminants. Clean Label Project notes heavy metals occur naturally.
  • It does not check that the label amounts are correct. That is a different test.

Look it up yourself

NSF Contents CertifiedNSF checked that what is in the bottle matches the label, and tested for certain contaminants.

What it checks

  • NSF reviews the formula and checks the label claims against lab results for the product.
  • NSF also tests for contaminants, including toxic elements such as lead, mercury, arsenic and cadmium.
  • NSF audits the manufacturing site against good manufacturing practices (GMP).

What it does not mean

  • It does not screen for substances banned in sport. That is the separate NSF Certified for Sport program.
  • It does not mean the product treats or prevents any condition, or that it works for any person.

Look it up yourself

NSF Certified Gluten-FreeNSF tested this product and audited where it is made to check it meets a gluten-free limit.

What it checks

  • NSF reviews the ingredients and tests the finished product for gluten.
  • NSF audits the manufacturing site to check that gluten cannot get into the product.

What it does not mean

  • It does not mean the product treats or helps with any condition, including celiac disease.
  • It covers gluten only. It does not cover other allergens or other claims.

Look it up yourself

More questions? We're here to help

How is it taken? What should I know first?

Suggested use: Mix 1 heaping scoop (2.2 g) into any hot or cold beverage that is free of caffeine, sugar substitutes, or carbonation. Do not mix with alcoholic beverages. Use 1-2 servings as needed or as directed by a physician.

Caution: Use only as directed. Consult your healthcare provider before use if you are contemplating pregnancy, pregnant, nursing, have any medical conditions, or use any medications. For adult use only. Keep this product out of reach of children. Do not use if tamper evident seal is broken or missing. Store in a cool dry place.

Please also read the full caution in the Learn the basics section, including the folate warning and the blood sugar caution.

What is in one scoop?

One serving is 1 scoop (2.2 g). It has 25 mcg Vitamin D3 (as Cholecalciferol), 500 mcg DFE Folate (as L-5-Methyltetrahydrofolate), 2,000 mg Myo-Inositol and 50 mg D-Chiro Inositol. The Daily Value (DV) is 125% for both Vitamin D3 and Folate. It is not established for the two inositols.

One container holds 2.33 oz (66 g), which is approximately 30 servings.

Why are folate and vitamin D3 added?

Folate plays a role in how your cells make DNA.* Vitamin D3 helps your body absorb and use calcium and phosphorus.* Each one is a nutrient with a known role in the body. Each scoop has 125% of the Daily Value of both.

What can I mix it with?

Use any hot or cold beverage that is free of caffeine, sugar substitutes, or carbonation. Do not mix it with alcoholic beverages.

Can I take it with other supplements or medicines?

Please use caution when taking this product alongside any other supplement or medication that can lower blood sugar levels as this combination may increase the risk of hypoglycemia.

This product contains 100% or more of the daily recommended amount of folate. Do not use it alongside other products that contain high amounts of folate, as this could lead to overconsumption of folate.

Talk with your healthcare provider before you combine this product with any medicine.

Can I take it if I am pregnant, planning pregnancy or nursing?

Talk with your healthcare provider first. Please read this before you use it: Consult your healthcare provider before use if you are contemplating pregnancy, pregnant, nursing, have any medical conditions, or use any medications.

This product contains 100% or more of the daily recommended amount of folate. Do not use it alongside other products that contain high amounts of folate.

Is there a difference between the powder and the capsules?

Both list the same amounts per serving: 25 mcg Vitamin D3, 500 mcg DFE Folate, 2,000 mg Myo-Inositol and 50 mg D-Chiro Inositol. A powder serving is 1 heaping scoop (2.2 g) mixed into a drink. A capsule serving is 4 capsules. The powder is an option if you would rather not swallow capsules. Capsules are easy to take on the go.

How long does one container last?

The container holds approximately 30 servings of 1 scoop. At 1 serving a day it lasts about 30 days. At 2 servings a day it lasts about 15 days.

Does it contain common allergens?

The product contains no animal products, gluten, soy, or nuts. It is made in a facility that also processes common food allergens. We cannot promise the complete absence of any allergen unless it is listed on the label.

What plant is the inositol made from?

Our Myo and D-Chiro Inositol is currently sourced from corn. This could change at any time, depending on sourcing.

Can I return it for a refund?

Yes. We offer a full refund on the purchase price minus shipping of our supplement products any time within 90 days (up to 3 bottles full or empty) for orders shipped in the United States. Please contact us through our Contact Us page for return instructions.

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Based on real orders from our customers.