Myo‑Inositol & D‑Chiro Inositol + MTHF Folate + Vitamin D3

Where does myo-inositol come from?

Myo-inositol is found widely in plants and animals, and your body also makes it. A lab study of 487 foods found the most in fruits, beans, grains and nuts. In grains it is stored as phytic acid.

A US food rule describes inositol prepared from an extract of corn kernels. Our inositol is currently sourced from corn, and this can change.

What does inositol look and taste like?

Inositol tastes sweet. One history of inositol science says its early name, inosite, came from that sweet taste. Our capsules are white or clear, with a white powder inside.

How does the body make, take in and break down myo-inositol?

Your body makes myo-inositol from glucose. Cells turn a form of glucose, glucose 6-phosphate, into inositol phosphate as the first step. Inositol is absorbed from the small intestine. The body also breaks myo-inositol down, and the first step opens its ring.

The enzyme for that step was isolated from pig kidneys. An enzyme is a substance that speeds up a chemical reaction in living things.

What do cells do with inositol?

Cells build myo-inositol into inositol lipids, which are fat-like molecules in the cell membrane. Cells also cut a small molecule, inositol trisphosphate, from one of these lipids. It carries a signal inside the cell. Provides Myo-Inositol and D-Chiro Inositol, two forms of inositol that cells use in cell signaling.*

The cell membrane is the thin layer that surrounds every living cell.

Where does the name myo-inositol come from?

Britannica says myo-inositol is named for muscle tissue, where it was first found in 1850. Scherer first isolated it and called it inosite. Maquenne fully purified it in 1887.

It was long counted as a B vitamin, but its status as a vitamin is uncertain.

What do researchers study about myo-inositol?

Researchers study how cells use inositol-containing molecules to pass signals. They measure how much myo-inositol common foods contain. They study how gut bacteria break down inositol from food.

These are topics of study. They are not claims about our product.

Where does D-chiro-inositol come from?

D-chiro-inositol is found in some plants and has also been detected in mammals. Buckwheat seeds hold it joined to a sugar, in compounds called fagopyritols. Soybeans are rich in D-pinitol, a close chemical relative of D-chiro-inositol.

Our inositol is currently sourced from corn, and this can change.

How does the body make and break down D-chiro-inositol?

Animal studies show that tissues can turn myo-inositol into D-chiro-inositol. In one animal study, the share that was changed differed from tissue to tissue. The enzyme that breaks down myo-inositol also breaks down D-chiro-inositol, at a slower rate.

What do researchers study about D-chiro-inositol?

Researchers study how tissues turn myo-inositol into D-chiro-inositol. They also study how the two forms are absorbed when people take them together. These are topics of study, not claims about our product.

Where does folate come from?

Folate is found in many foods. Dark green leafy vegetables, fruits, nuts, beans, peas, eggs, dairy products, meat and grains all contain it. Fortified foods and most supplements use a form called folic acid. Some supplements use 5-MTHF, as ours does.

How does the body take in and store folate?

Your gut changes food folate to a simpler form before it absorbs it. Before folate enters the blood, the body changes it to methyl or formyl forms. About half of the body's folate is stored in the liver. Folate (as L-5-MTHF) plays a role in how your cells make DNA.*

What does 500 mcg DFE mean?

DFE stands for dietary folate equivalents. It is a unit made so that different forms of folate can be compared. Each serving has 500 mcg DFE, which is 125% of the Daily Value.

NIH says the factors for changing 5-MTHF amounts into DFE have not been formally established.

Where does the name folate come from?

The name comes from the Latin word folium, which means leaf. In 1941, scientists described folic acid that they had taken from 4 tons of spinach.

What do researchers study about folate and 5-MTHF?

Researchers study how to measure the amount of folate in blood. They compare blood folate after people take folic acid or 5-MTHF. They also study how folate supplies the small carbon units that cells add to DNA.

These are topics of study. They are not claims about our product.

Where does vitamin D3 come from?

Your skin makes vitamin D3 when UVB rays from sunlight reach it. Few foods contain vitamin D. Fatty fish and fish liver oils are among the top food sources.

Vitamin D3 for supplements is typically made from lanolin, which comes from sheep's wool. A version sourced from lichen also exists.

What does vitamin D3 look and smell like?

Pure vitamin D3 forms fine, colorless crystals. It has no smell. It does not dissolve in water.

How does the body take in and change vitamin D?

Vitamin D from sun, food or supplements is not active at first. The liver changes it to 25-hydroxyvitamin D. The kidneys then make the active form, 1,25-dihydroxyvitamin D. Vitamin D3 helps your body absorb and use calcium and phosphorus.*

Vitamin D is absorbed in the small intestine.

Where does the name vitamin D come from?

Vitamin D got its letter because it was found after vitamins A, B and C. Vitamin D2 was the first form to be isolated and identified. Scientists identified vitamin D3 in 1937.

What do researchers study about vitamin D3?

Researchers compare vitamin D2 and vitamin D3 supplements in trials. They measure a marker in blood called 25-hydroxyvitamin D. Expert panels also review studies to set daily intake values.

These are topics of study. They are not claims about our product.