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Myo-Inositol & D-Chiro Inositol + MTHF Folate + Vitamin D3
Myo-Inositol & D-Chiro Inositol + MTHF Folate + Vitamin D3
Myo-Inositol & D-Chiro Inositol + MTHF Folate + Vitamin D3

Myo-Inositol & D-Chiro Inositol + MTHF Folate + Vitamin D3

120 Vegetarian Capsules 

A blend of 2,000mg of Myo-Inositol and 50mg of D-Chiro Inositol (following the body's normal ratio of 40:1) with added MTHF Folate and Vitamin D3 to support healthy hormone levels, menstrual cycles, ovarian health, and reproductive health.

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Support Your Monthly Well-Being and Reproductive Health
BENEFITS
SUGGESTED USE
CAUTION
Research

Supports Hormonal Health

Blood glucose control, reproductive support, ovarian support, hormone support, improved IVF outcomes.

Supports Healthy Fetal Development

Our product provides the recommended daily amounts of folate and vitamin D to support healthy development of the neural tube and associated structures during embryonic/fetal development and may even promote full-gestation births. 

Supports Bone Health and Insulin Sensitivity

The inositols and vitamin D can help pregnant and lactating women and older adults support their blood glucose levels and bone health by aiding in hormone balance and calcium absorption. 

Suggested Use:

Take 4 capsules (1 serving) daily, preferably with a meal, or as directed by a physician. For those with a sensitive constitution, take ½ of a serving (2 capsules) at once, twice per day.

Caution: 

Use only as directed. Consult your healthcare provider before use if you are contemplating pregnancy, pregnant, nursing, have any medical conditions, or use any medications. For adult use only. Keep this product out of reach of children. Do not use if tamper evident seal is broken or missing. Store in a cool, dry place. 

Please use caution when taking this product alongside any other supplement or medication that can lower blood sugar levels as this combination may increase the risk of hypoglycemia. 

[1] Williams, T., Mortada, R., & Porter, S. (2016). Diagnosis and treatment of polycystic ovary syndrome. American Family Physician, 94(2), 106-113. Retrieved from: https://www.aafp.org/afp/2016/0715/p106.html#sec-5

[2] Benelli, E., Del Ghianda, S., Di Cosmo, C., & Tonacchera, M. (2016). A combined therapy with myo-inositol and d-chiro-inositol improves endocrine parameters and insulin resistance in PCOS young overweight women. International Journal of Endocrinology. DOI: http://dx.doi.org/10.1155/2016/3204083

[3] Sortino, M. A., Salomone, S., Carruba, M. O., & Drago, F. (2017). Polycystic ovary syndrome: insights into the therapeutic approach with inositols. Journal Frontiers in Pharmacology, 8(341), 1-13. DOI: 10.3389/fphar.2017.00341

[4] Troisi, J., Cinque, C., Giugliano, L., Symes, S., Richards, S., Adair, D., Cavallo, P., Sarno, L., Scala, G., Caiazza, M., & Guida, M. (2019). Metabolomic change due to combined treatment with myo-inositol, d-chiro-inositol and glucomannan in polycystic ovarian syndrome patients: a pilot study. Journal of Ovarian Research, 12(25). DOI: https://doi.org/10.1186/s13048-019-0500-x 

[5] Kalra, B., Kalra, S., & Sharma, J. (2016). The inositols and polycystic ovary syndrome. Indian Journal of Ednocrinology and Metabolism, 20(5), 720-724. DOI: 10.4103/2230-8210.189231 

[6] Unfer, V., Facchinetti, F., Orru, B., Giordani, B., & Nestler, J. (2017). Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Endocrine Connections, 6(8), 647-658. DOI: 10.1530/EC-17-0243 

[7] Centers of Disease Control and Prevention. (2018, April 11). Folic acid. https://www.cdc.gov/ncbddd/folicacid/faqs/faqs-general-info.html

[8] Melitis, C. Folate vs. folic acid – facts about vitamin B. American Pregnancy Association. https://americanpregnancy.org/infertility/folate-vs-folic-acid-what-you-need-to-know/ 

[9] National Institutes of Health. (2020, March 11). Folate. https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/ 

[10] Lynch, B. L-methylfolate, methylfolate, 5-MTHF, L-5-MTHF. What is the difference?! http://mthfr.net/l-methylfolate-methylfolate-5-mthf/2012/04/05/ 

[11] Stracquadanio, M., Ciotta, L., & Palumbo, M. A. (2018). Effects of myo-inositol, gymnemic acid, and L-methylfolate in polycystic ovary syndrome patients. Gynecological Endocrinology, 34(6), 495-501. DOI: 10.1080/09513590.2017.1418852 

[12] Scaglione, F., & Panzavolta, G. (2014). Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica, 44(5), 480-488. DOI: 10.3109/00498254.2013.845705 

[13] Obeid, R., Holzgreve, W., & Pietrzik, K. (2013). IS 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects? Journal of Perinatal Medicine, 41(5), 469-483. DOI: 10.1515/jpm-2012-0256 

[14] Fu, L., Dai, L., Li, X., Zhang, K., & Bai, Y. (2014). Association of methylenetetrahydrofolate reductase gene C677T polymorphism with polycystic ovary syndrome risk: a systematic review and meta-analysis update. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 172, 56-61. DOI: 10.1016/j.ejogrb.2013.10.001 

[15] Diwaker, A., & Kishore, D. (2018). Evaluation of plasma homocysteine levels in patients of PCOS. The Journal of the Association of Physicians of India, 66(10), 17-20. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/31317701/?from_term=pcos+homocysteine&from_pos=1 

[16] Schachter, M., Raziel, A., Friedler, S., Strassburger, D., Bern, O., & Ron-El, R. (2003). Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine. Human Reproduction, 18(4), 721-727. DOI: 10.1093/humrep/deg190 

[17] Badawy, A., State, O., Sh Abd El Gawad, S., & Abd El Aziz, O. (2007). Plasma homocysteine and polycystic ovary syndrome: the missed link. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 131(1), 68-72. DOI: 10.1016/j.ejogrb.2006.10.015

 [18] Saadeh, N., Alfaqih, M. A., Mansour, H., Khader, Y. S., Saadeh, R., Al-Dwairi, A., & Nusier, M. (2018). Serum homocysteine is associated with polycystic ovary syndrome in Jordan. Biomedical Reports, 9(5), 439-445. DOI: 10.3892/br.2018.1149 

[19] Linus Pauling Institute. (2017, October). Vitamin D. https://lpi.oregonstate.edu/mic/vitamins/vitamin-D

[20] Harvard T.H. Chan School of Public Health. (2020, March). Vitamin D. https://www.hsph.harvard.edu/nutritionsource/vitamin-d/ 

[21] Krul-Poel, Y. H. M., Snackey, C., Louwers, Y., Lips, P., Lambalk, C. B., Laven, J. S. E., & Simsek, S. (2013). The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review. European Journal of Endocrinology, 169(6), 853-865. DOI: 10.1530/EJE-13-0617

[22] Krul-Poel, Y. H. M., Koenders, P. P., Steegers-Theunissen, R. P., Ten Boekel, E., Ter Wee, M. M., Louwers, Y., Lips, P., Laven, J. S. E., & Simsek, S. (2018). Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): a cross-sectional study. PLoS One, 13(12). DOI: 10.1371/journal.pone.0204748 

[23] He, C., Lin, Z., Robb, S. W., & Ezeamama, A. E. (2015). Serum vitamin D levels and polycystic ovary syndrome: a systematic review and meta-analysis. Nutrients, 7(6), 4555-4577. DOI: 10.3390/nu7064555 [24] Thomson, R. L., Spedding, S., Buckley, J. D. (2012). Vitamin D in the aetiology and management of polycystic ovary syndrome. Clinical Endocrinology, 77(3), 343-350. DOI: 10.1111/j.1365-2265.2012.04434.x 

[25] Dastorani, M., Aghadavod, E., Mirhosseini, N., Foroozanfard, F., Modarres, S. Z., Siavashani, M. A., & Asemi, Z. (2018). The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization. Reproductive Biology and Endocrinology, 16(1), 94. DOI: 10.1186/s12958-018-0413-3 

[26] Javed, Z., Papageorgiou, M., Deshmukh, H., Kilpatrick, E. S., Mann, V., Corless, L., Abouda, G., Rigby, A. S., Atkin, S. L., & Sathyapalan, T. (2019). Nutrients, 11(1), 188. DOI: 10.3390/nu11010188 

[27] Kagowska, K., Bajerska, J., & Jamka, M. (2018). The role of vitamin D oral supplementation in insulin resistance in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Nutrients, 10(11), 1637. DOI: 10.3390/nu10111637

Core essential ingredients

Myo-Inositol

Part of the Vitamin B complex family, Myo-Inositol has been shown to promote female fertility through supporting hormone balance and ovarian function.

D-Chiro Inositol

D-Chiro Inositol supports balanced metabolic health for women.

Vitamin D3 (Cholecalciferol) 

Vitamin D3 is organically produced in the body when the skin is exposed to UVB rays from the sun, which triggers its synthesis. Vitamin D3 can also be obtained from the diet in animal foods (fatty fish, egg yolk).

Folate (as L-5-Methyltetrahydrofolate or MTHF) 

MTHF is the predominant and bioactive form of folate, or Vitamin B9. Both the synthetic form (folic acid) and the natural folate form (found in foods) are converted in the body to MTHF.

Customer Reviews

Based on 140 reviews
85%
(119)
7%
(10)
3%
(4)
2%
(3)
3%
(4)
A
Allyson Sparrow
Helped balance my hormones

I tested my progesterone before taking these, it was undetectable it was so low. Then my doctor just tested me after a couple months taking these regularly, and my hormones tested normal! I have NEVER had a period multiple months in a row at the same time of month until now! 3 months of being normal! Thank you!

A
Anonymous

Struggling with PCOS my whole life, I was thrilled when I learned about inositol and all the amazing things it is suppose to do for hormonal balancing and restoring a normal cycle. Supplements can be so hard to navigate so when I found one with good reviews, cute branding, and affordability, I was sold! I’ve been taking this supplement for a just about a year now and honestly, I haven’t noticed any changes. My hormones and blood sugar is still just as all over the place and my cycle hasn’t returned. Maybe that’s just my body, however one thing I did noticed was the inconsistency in the product itself. Some of the capsules are filled to the max while others have a good sized gap. This isn’t just a fluke with my most recent purchase, it’s been consistent with all my purchases. My other concern is just how many capsules a dosage is. I feel like it could easily fit into just two larger capsules instead of four small ones (especially since they aren’t being filled consistently). I have hope for the future do this product, I can see what they are trying to do with it and I’m so happy for those who have had great results, but this product is not for me. I would love to see consistently and larger capsule sizes.

C
C.C.
Amazing

I started taking these capsules in December 2021 to regulate my cycle. My cycles were long (50-90+ days) and it showed up whenever it wanted. I noticed a difference in my mood fairly quickly, (felt lighter and generally happier) and had less cravings for sweet snacks. My period showed up quickly too, I can't remember the exact number of days but within the first 10 days of taking the supplement for sure. My goal with taking this supplement was to regulate my cycles enough to get pregnant, we had been trying for almost 2.5 years before starting this supplement. I finally got a positive pregnancy test in May 2022, and I'm owing it to wholesome story. Nothing else worked for us. I recommend this product wholeheartedly to anyone trying to conceive. I now have a super cute three-month-old baby and it seems so unreal after waiting for so long. Also, another happy side effect of taking this product was that because I was snacking less, I lost 25 pounds before conceiving.

J
Juyi Hsieh

Myo-Inositol & D-Chiro Inositol + MTHF Folate + Vitamin D3

C
Christine Lindner
Loving this Supplement

I am 37 and have had lifelong struggles with my menstrual health. I started taking this after going to my doctor convinced I was getting close to peri-menopause. I started noticing changes in the first month: less moodiness, sugar cravings and the feeling I was always starving disappeared, and I lost 10 pounds! That part was a bonus because I was actually happy at my original weight, seems to have been mostly inflammation that just melted away.